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Bioactive Compounds from Natural Sources: Isolation Corrado Tringali, Ebooks Corporation.
Publisher: CRC Press

The novel drug discovery program focuses on activity guided isolation and structure elucidation of bioactive compounds from natural sources with high throughput screening. All of this has to be done whilst maintaining or Elena's main research includes the study and development of new extraction processes based on the use of sub- and supercritical fluids to isolate bioactive compounds from natural products, and also the development of advanced analytical methods for foodomics. Ling (Wenyujin), is used as an anti-cancer drug in China. In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both in vitro and in vivo. This book on medicinal plant biotechnology covers recent developments in this field. For example, β-elemene, a compound isolated from Curcuma wenyujin Y. A DNA fragmentation assay was conducted on isolated genomic DNA, a TUNEL assay was used to determine the mode of cell death and Western blotting was used to evaluate the expression levels of Bax and Bcl-2. Bioactive Compounds from Natural Sources: Isolation. Medicinal herbs are main sources of new drugs. Moreover, they should also consider developing methods able to consume fewer resources. Mazur X, Becker U, Anke T, Sterner O: Two new bioactive diterpenes from Lepista scordida. The need to develop more effective and less toxic anti-cancer drugs has prompted researchers to explore new sources of pharmacologically active compounds. As mining, purifying and characterizing novel bioactive compounds from marine sources, high through-put screening for biological activity, developing efficient isolation processes and pilot scale production of bioactives.